St. John’s Wort (Hypericum perforatum) to a placebo for treating major depression of moderate severity. St. John’s wort is useful in treating mild to moderately severe depression. It is taken by many people for the relief of mild to moderate depression, depressed mood or loss of interest in normal activities that lasts most of the day nearly every day for at least 2 weeks; this mood can last longer if untreated. Other than depressed mood or loss of interest, symptoms include at least four of the following: significant weight loss or gain, sleep disturbances, agitation or unusual slowness, fatigue or loss of energy, feelings of worthlessness or guilt, lack of concentration, or recurrent thoughts of death or suicide.
Recommendations: Take two capsules twice daily, preferably with food. For maximum benefit use for at least 2 months.
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