Best SAMe 400 contains 400mg of active SAMe in each tablet. Doctor’s Best utilizes only the highest quality Italian SAMe available on the market. This ensures the most potent SAMe product with the highest percentage fo the active S,S form per serving.
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system.
Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. Methylation occurs billions of times daily in the many organs of the body.
SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. It is also required for the biosynthesis of critical neurotransmitters and hormones.
SAMe is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine. It is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine. SAMe is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteogylcans in joint connective tissue.
All SAM-e supplements are not created equal. During the manufacture of SAMe, two forms are produced known as the S,S and the R,S isomers. The S,S isomer is the biologically active form in the human body, whereas the R,S form is considered to be inactive. Best SAMe 400 utilizes Italian SAMe to yield the highest available percentage of the active pure S,S form on the market. Best SAMe 400 contains an average of nearly 74% of the active S,S form.
Other SAMe products contains as little as only 50% of the active form. A higher content of the active form yields a more potent product. The molecule SAMe itself is highly unstable. It will degrade quickly in conditions of heat, light, and moisture. To increase its stability, it must be formed into a salt. It is important to note that SAM e used for dietary supplements exists in a number of salt forms. Best SAMe utilizes the SAMe tosylate fisulfate salt form. This salt has been the most extensively utilized form in clinical trials of SAMe. Because of the unstable nature of pure SAMe it is also highly susceptible to degradation in an acidic environment like the stomach. To be utilized effectively, it must pass through the stomach for absorption in the small intestine. For this reason, only enteric-coated formulas should be used. Best SAMe tablets are enteric-coated to maximize the utilization and benefits of the SAMe by the body.
Benefits: Enhances Mood and Neural Function
Safety: SAMe has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials. Individuals diagnosed with manic depression should avoid SAMe supplementation, as it may aggravate the manic phase.