Boswellia serrata, also known as shallaki or boswellic acid, is a natural and safe herb for optimum joint health. It has traditionally been used as incense because of its fragrant properties. One active constituent, boswellic acid, is a pyrazoline derivative shown to be very effective in supporting healthy joints. Like its cousin guggul, boswellia has many cholesterol and triglyceride lowering properties. One of the principal constituents in the gum resin is boswellic acid, which exhibits anti-inflammatory activity.
Boswellia Serrata has been used extensively in ayurveda for joint support. Also known as salai guggul, it is like its cousin guggul in offering broad health and immunomodulating benefits. The gum resin is used as an ointment for sores and has anti-inflammatory, antiatherosclerotic and anti-arthritic activities. The nonphenolic fraction of the gum resin had marked sedative and analgesic action. The gum is a well-known household fumigant and is used as an anti-inflammatory agent when applied externally. Internally, besides being antiarthritic, it has expectorant effects. It also reduces body weight.
In clinical trials, promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, crohn’s disease, bronchial asthma and peritumoral brains edemas. Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, noncompetitive inhibition of 5-lipoxygenase. Boswellic acids binding to the enzyme trigger the effect. Moreover certain boswellic acids have been described to inhibit elastase in leukocytes, to inhibit proliferation, induce apoptosis and to inhibit topoisomerases of leukoma- and glioma cell lines. A series of chronic inflammatory diseases.