L-Carnitine is a vitamin-like nutrient that is synthesized in the body, using the amino acids lysine and methionine as precursors.
Because the body produces L-Carnitine on its own, it cannot be classified as a vitamin, even though it has functions similar to B vitamins.
Fumarate is also a natural compound found in the body. Fumarate serves as an intermediate in the Krebs cycle, a key cellular energy-producing process.
L-Carnitine and Fumarate both play important roles in energy metabolism.
Best L-Carnitine contains BIOSINT™ L-Carnitine Fumarate, which is made in Italy by Sigma Tau Health Science.
It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production.
No biotechnology or genetically modified organisms are involved.
L-Carnitine Fumarate is certified GMO free, BSE safe, pesticide free and Kosher.
It is also ISO 9002 certified and NNFA GMP certified.
L-Carnitine Fumarate is highly stable and bioavailable.
Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives are used in clinical trials.
Sigma Tau Health Science has the only FDA-approved (1984) pharmaceutical batch process system for consistent L-Carnitine quality, and has been manufacturing L-Carnitine derivatives for 30 years
Helps the body burn fat for energy
L-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion.
Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine.
The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body’s L-Carnitine content is stored in the form of acyl-carnitine.
The mitochondrion is the cell’s energy-generating furnace.
Called an “organelle,” the mitochondrion is a self-contained structure inside the cell.
Like all cellular structures, the mitochondrion is surrounded by a membrane.
This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter.
On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation.
One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.”
L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.